Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies
Current Hi-C analysis approaches are unable to account for reads that align to multiple locations, and hence underestimate biological signal from repetitive regions grand love red heart reposado tequila of genomes.We developed and validated mHi-C, a multi-read mapping strategy to probabilistically allocate Hi-C multi-reads.mHi-C exhibited superior